Gennaro, the son of Lucretia Borgia, lives unaware of the identity of his mother, who has married the Duke of Ferrara. After Lucretia's brother is killed by five conspirators, the fathers of Gennaro's dearest friends, Lucretia tortures the old men to death. Later, Gennaro and his companions journey to Lucretia's domain, and she sees her son for the first time. The Duke, who believes him to be her lover, poisons him, but Lucretia administers the antidote in time and saves his life. Then she schemes to poison her sons' five friends for their fathers' mistake.
Florence Reed
Lucretia Borgia
William E. Shay
The Duke of Ferrara
Stephen Grattan
Lucretia's Brother
Richard Barthelmess
Gennaro
Alex Shannon
Rustighello
A.G. Parker
Maffio
M.J. Briggs
Astolpo
Edward Thorne
Jeppo
Elmer Patterson
Liverretto
Tony Merlo
Petrucci
Henry Armetta
The Jester
William Welsh
Gubetta
Juliet Brenon
Blanca
Jane Fearnley
Princess Negroni
Henrietta Gilbert
Flametta
